James B. Rand, Ph.D.
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Member,
Molecular and Cell Biology Research Program
H.A. and Mary
K. Chapman Chair in Medical Research
Adjunct Professor, Department of Cell
Biology, University of Oklahoma Health Sciences Center
Adjunct Professor,
Department of Zoology, University of Oklahoma
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B.A., Hofstra University, Hempstead, NY
(cum laude), 1969
Ph.D., The Rockefeller University, New York,
1975
Joined OMRF Scientific Staff in 1989.
e-mail: James-Rand@omrf.ouhsc.edu
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The synthesis and loading of neurotransmitter
molecules into synaptic vesicles and the regulated release of the
synaptic vesicles are crucial to proper synaptic function. In the
simple, 302-cell nervous system of the soil nematode
Caenorhabditis elegans, we can apply powerful tools of
genetics and molecular biology to analyze synaptic vesicle function
and its regulation.
Cholinergic neurons in C. elegans labeled with Green Flourescent Protein (GFP).
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One set of projects in my laboratory involves
the analysis of acetylcholine synthesis and its transport into
synaptic vesicles - we have cloned and sequenced the genes required
for these processes, and we have studied mutants which are partially
or totally deficient in these functions.
The other projects include
studies on the mechanism and regulation of neurotransmitter release
by synaptic vesicles - this includes the genetic, behavioral, and
molecular analysis of genes involved in synaptic vesicle function
and recycling.
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Rand, J. B., Duerr, J. S., and Frisby, D. L., 2000. Neurogenetics
of vesicular transporters in C. elegans. FASEB J. 14:2414-2422.
Full Text (Adobe PDF)
Miller, K. G. and Rand, J. B., 2000. A role for RIC-8 (synembryn)
and GOA-1 (Goa)
in regulating a subset of centrosome movements during early embryogenesis
in Caenorhabditis elegans. Genetics 156:1649-1660.
Full Text (Adobe PDF)
Duerr, J. S., Gaskin, J. G., and Rand, J. B., 2001. Colocalization
of the vesicular acetylcholine transporter (VAChT) and the vesicular
monoamine transporter (VMAT) in identified neurons of Caenorhabditis
elegans. Am. J. Physiol. Cell Physiol., 280:C1616-C1622.
Full Text (Adobe PDF)
Lickteig, K.M., Duerr, J.S., Frisby, D.L., Hall, D.H., Rand, J.B.,
and Miller, D.M., III, 2001. Regulation of neurotransmitter vesicles
by the homeodomain protein UNC-4 and its transcriptional co-repressor
UNC-37/Groucho in Caenorhabditis elegans cholinergic motor
neurons. J. Neurosci. 21: 2001-2014. Full Text (Adobe PDF)
Click here for additional publications.
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1964-1969 |
National Merit Scholar |
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1969-1971 |
NSF Graduate Fellowship |
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1975 |
Gosney Foundation Postdoctoral
Fellowship |
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1976-1977 |
American Cancer Society Postdoctoral
Fellowship |
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1978 |
Muscular Dystrophy Association Postdoctoral
Fellowship |
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1995 |
The Gaylord Prize for Scientific
Research |
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1996-2001 |
Merrick Distinguished Research Scientist |
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2001- present |
H.A. and Mary K. Chapman Chair in Medical Research |
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1975-1979 |
Postdoctoral Fellow, Laboratory of Richard L.
Russell, California Institute of Technology, Pasadena, CA
and University of Pittsburgh, Pittsburgh, PA |
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1980-1985 |
Research Assistant Professor, Department of
Biological Sciences, University of Pittsburgh, Pittsburgh,
PA |
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1986-1989 |
Associate Scientist, Department of Zoology,
University of Wisconsin, Madison, WI |
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1986-1987 |
Senior Scientist, Department of Zoology,
University of Wisconsin, Madison, WI |
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1987-1994 |
Associate Member, Oklahoma Medical Research
Foundation |
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1994-present |
Member, Oklahoma Medical Research
Foundation |
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Society for Neuroscience
Genetics Society of
America
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Serves on NIH Reviewers Reserve; reviews manuscripts
for Genetics and for Journal of Neuroscience; reviews grants for
National Science Foundation
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